Computational Modeling of Sodium Channel Inactivation
نویسندگان
چکیده
منابع مشابه
Molecular modeling and dynamics of the sodium channel inactivation gate.
The intracellular linker L(III-IV) of voltage-gated sodium channels is known to be involved in their mechanism of inactivation. Its primary sequence is well conserved in sodium channels from different tissues and species. However, the role of charged residues in this region, first thought to play an important role in inactivation, has not been well identified, whereas the IFM triad (I1488-M1490...
متن کاملMechanisms of sodium channel inactivation.
Rapid inactivation of sodium channels is crucial for the normal electrical activity of excitable cells. There are many different types of inactivation, including fast, slow and ultra-slow, and each of these can be modulated by cellular factors or accessory subunits. Fast inactivation occurs by a 'hinged lid' mechanism in which an inactivating particle occludes the pore, whereas slow inactivatio...
متن کاملInactivation of the Sodium Channel
A B S X R A C T Gating current (I~) has been studied in relation to inactivation of the Na channels. No component of lg has the time course of inactivation; apparent ly little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement dur ing a pulse and...
متن کاملInactivation of the Sodium Channel
A B S X R A C T Gating current (I~) has been studied in relation to inactivation of the Na channels. No component of lg has the time course of inactivation; apparent ly little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement dur ing a pulse and...
متن کاملInactivation of the Sodium Channel
A B S X R A C T Gating current (I~) has been studied in relation to inactivation of the Na channels. No component of lg has the time course of inactivation; apparent ly little or no charge movement is associated with this step. Inactivation nonetheless affects Ig by immobilizing about two-thirds of gating charge. Immobilization can be followed by measuring ON charge movement dur ing a pulse and...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2016
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2015.11.639